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KMID : 0895820100200020035
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Journal of Oriental Rehabilitation Medicine
2010 Volume.20 No. 2 p.35 ~ p.50
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The Inhibitory Effects of So-yangin Biman-bang on the Obese-Mice Induced by High-Fat Diet
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Park In-Sun
Yoon Il-Ji
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Abstract
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Objectives : In order to investigate the effects of So-yangin Biman-bang(here in after referred to BM) on the obese gene and obese inhibitory, C57BL/6 mice were distinctively induced by high fat diet.
Methods : C57BL/6 mice were divided into four groups(normal, high fat diet with control, high fat diet with Reductil(here in after referred to RDT), high fat diet with BM extract) and have been fed for 8 weeks. Through observing the process, the weight change of the adipocytes in body and liver, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, glucose, leptin change in the serum, the expression of β3AR and leptin gene in 3T3-L1 cell and primary adipocyte cell.
Results : The following results have been found in this study. 1. Losing weight have significantly been shown. 2. The weight change of the body adipocyte and liver have been decreased but no significance has been found. 3. With close observation on the change of blood, HDL-cholesterol has positively been increased in numbers but the level of glucose, LDL-cholesterol, triglyceride have distinctively been decreased. 4. The manifestation of β3AR in 3T3-L1 cell and primary adipocyte cell have shown a definite increase in numbers but the manifestation of leptin has shown certain decrease in its amount.
Conclusions : As results of this, So-yangin Biman-bang is thought to be effective in metabolic syndrom and lipid metabolism disorder that can possibly be occurred by obesity control and treatment. The clinical research will be needed in order to apply to So-yangin constitution in the future.
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KEYWORD
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So-yangin Biman-bang(BM), Obese gene, Obese inhibitory, Adipocyte, β3AR, Leptin, Liver tissue
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